Julie A. Woodward, MD

UV radiation from sun exposure is a risk factor for most types of skin cancer.¹ Despite comprising only 1% of the body's surface area, the periocular region is the location of approximately 5% to 10% of skin cancers described in one US study.² The efficacy of sunscreen in preventing skin cancer is widely accepted, and the American Academy of Dermatology recommends application of broad-spectrum UVA/UVB sunscreen with a sun protection factor of 30 or higher to help prevent skin cancer.^3-5

RELATED ARTICLE: Sun Protection for Infants: Parent Behaviors and Beliefs

Reducing the risk of skin cancer from sun exposure relies on many factors, including completeness of application. A number of studies have demonstrated incomplete sunscreen application on the hairline, ears, neck, and dorsal feet.^6-8 The purpose of this study was to assess the completeness of facial sunscreen self-application in oculofacial surgery patients using UV photography.

Methods

This single-site, cross-sectional, qualitative study assessed the completeness of facial sunscreen self-application among patients from a single surgeon's (J.A.W.) cosmetic and tertiary-care oculofacial surgery practice at the Duke Eye Center (Durham, North Carolina) between March 2016 and May 2016. Approval from the Duke University institutional review board was obtained, and the research adhered to the tenets of the Declaration of Helsinki and complied with the Health Insurance Portability and Accountability Act. Informed consent was obtained from all patients, and patients could elect to provide specific written consent for publication of photographs in scientific presentations and publications. Patients younger than 18 years of age; those with known sensitivity to sunscreen or its ingredients; and those with an active lesion, rash, or open wound were excluded from the study.

After obtaining informed consent, patients were photographed using a camera with a UV lens in natural outdoor lighting, first without sunscreen and again after self-application of a sunscreen of their choosing using their routine application technique. Completeness of sunscreen application was graded independently by 3 oculofacial surgeons (N.A.L., J.L., J.A.W.) as complete, partial, none, or cannot determine for 15 facial regions. The majority response was used for analysis.

Results

Forty-four patients were enrolled in the study. Six patients were disqualified due to use of mineral-based formulations (zinc oxide and/or titanium dioxide), as these sunscreens could not be visualized using UV photography. The age range of the remaining 38 patients was 28 to 74 years; 26% (10/38) were men and 74% (28/38) were women.

Complete sunscreen application was most frequently performed on the cheeks (97% [37/38]), chin (95% [36/38]), forehead (92% [35/38]), and temples (92% [35/38]). Complete absence of sunscreen coverage was most common on the lower eyelid margin (84% [32/38]), upper eyelid margin (82% [31/38]), medial canthus (71% 27/38]), and upper eyelid (66% [25/38])(Table)(Figure).

Comment

UV radiation-related skin cancers frequently occur in the periocular area, presumably because it is a frequent site of UV exposure. Clothing, sunglasses, and hats can be used to aid in protection from UV radiation, but these products are only regulated by the US Food and Drug Administration if the product claims to prevent skin cancer. Sunscreen is a proven method of protection from UV radiation and the prevention of skin cancer but must be properly applied for it to be effective.^1,2,5,6 Incomplete sunscreen application has been demonstrated in numerous studies. Lademann et al7 studied sunscreen application among 60 beachgoers in Germany and found they typically missed the hairline, ears, and dorsal feet. In a study of 10 women with photosensitivity in England who were asked to apply sunscreen in their routine manner, Azurdia et al⁶ found the posterior neck, lateral neck, temples, and ears, respectively, were the most frequently missed sites. Yang et al⁸ assessed sunscreen application in 39 dermatologists and 41 photosensitive patients in China and found the neck, ears, dorsal hands, hairline, temples, and perioral region, respectively, were most commonly left unprotected.

Our study investigated detailed facial self-application of sunscreen and found excellent coverage of the larger facial units such as the forehead, cheeks, chin, and temples. The brow, medial canthus, lateral canthus, and upper and lower eyelids and eyelid margins were infrequently protected with sunscreen during routine application. Our opinion is that patients are unaware that eyelid sunscreen application is important. They may be afraid that the products will sting or cause damage if they get in the eyes. Although some products do sting if they get into the eyes, there is no evidence that sunscreens cause injury to the eyes. The US Food and Drug Administration does not have clear guidelines about applying sunscreens in the periocular area, but in general, mineral blocks are recommended because they have less chance of irritation. Several companies make such products that are designed to be applied to the eyelids.

Limitations of our study included a small sample size and a majority female demographic, which may have affected the results, as women generally are more familiar with the application of lotions to the face. Additionally, the patients were recruited from a tertiary-care clinic and may have had periocular malignancy or may have previously received counseling on the importance of sunscreen use.

Conclusion

Cancer reconstruction of the periocular area is challenging, and even in the best of hands, a patient's quality of life may be negatively affected by postreconstructive appearance or suboptimal function, resulting in ocular exposure. The authors recommend counseling patients on the importance of good sun protection habits, including daily application of sunscreen to the face and periocular region to prevent malignancy in these delicate areas.

UV radiation from sun exposure is a risk factor for most types of skin cancer.¹ Despite comprising only 1% of the body's surface area, the periocular region is the location of approximately 5% to 10% of skin cancers described in one US study.² The efficacy of sunscreen in preventing skin cancer is widely accepted, and the American Academy of Dermatology recommends application of broad-spectrum UVA/UVB sunscreen with a sun protection factor of 30 or higher to help prevent skin cancer.^3-5

RELATED ARTICLE: Sun Protection for Infants: Parent Behaviors and Beliefs

Reducing the risk of skin cancer from sun exposure relies on many factors, including completeness of application. A number of studies have demonstrated incomplete sunscreen application on the hairline, ears, neck, and dorsal feet.^6-8 The purpose of this study was to assess the completeness of facial sunscreen self-application in oculofacial surgery patients using UV photography.

Methods

This single-site, cross-sectional, qualitative study assessed the completeness of facial sunscreen self-application among patients from a single surgeon's (J.A.W.) cosmetic and tertiary-care oculofacial surgery practice at the Duke Eye Center (Durham, North Carolina) between March 2016 and May 2016. Approval from the Duke University institutional review board was obtained, and the research adhered to the tenets of the Declaration of Helsinki and complied with the Health Insurance Portability and Accountability Act. Informed consent was obtained from all patients, and patients could elect to provide specific written consent for publication of photographs in scientific presentations and publications. Patients younger than 18 years of age; those with known sensitivity to sunscreen or its ingredients; and those with an active lesion, rash, or open wound were excluded from the study.

After obtaining informed consent, patients were photographed using a camera with a UV lens in natural outdoor lighting, first without sunscreen and again after self-application of a sunscreen of their choosing using their routine application technique. Completeness of sunscreen application was graded independently by 3 oculofacial surgeons (N.A.L., J.L., J.A.W.) as complete, partial, none, or cannot determine for 15 facial regions. The majority response was used for analysis.

Results

Forty-four patients were enrolled in the study. Six patients were disqualified due to use of mineral-based formulations (zinc oxide and/or titanium dioxide), as these sunscreens could not be visualized using UV photography. The age range of the remaining 38 patients was 28 to 74 years; 26% (10/38) were men and 74% (28/38) were women.

Complete sunscreen application was most frequently performed on the cheeks (97% [37/38]), chin (95% [36/38]), forehead (92% [35/38]), and temples (92% [35/38]). Complete absence of sunscreen coverage was most common on the lower eyelid margin (84% [32/38]), upper eyelid margin (82% [31/38]), medial canthus (71% 27/38]), and upper eyelid (66% [25/38])(Table)(Figure).

Comment

UV radiation-related skin cancers frequently occur in the periocular area, presumably because it is a frequent site of UV exposure. Clothing, sunglasses, and hats can be used to aid in protection from UV radiation, but these products are only regulated by the US Food and Drug Administration if the product claims to prevent skin cancer. Sunscreen is a proven method of protection from UV radiation and the prevention of skin cancer but must be properly applied for it to be effective.^1,2,5,6 Incomplete sunscreen application has been demonstrated in numerous studies. Lademann et al7 studied sunscreen application among 60 beachgoers in Germany and found they typically missed the hairline, ears, and dorsal feet. In a study of 10 women with photosensitivity in England who were asked to apply sunscreen in their routine manner, Azurdia et al⁶ found the posterior neck, lateral neck, temples, and ears, respectively, were the most frequently missed sites. Yang et al⁸ assessed sunscreen application in 39 dermatologists and 41 photosensitive patients in China and found the neck, ears, dorsal hands, hairline, temples, and perioral region, respectively, were most commonly left unprotected.

Our study investigated detailed facial self-application of sunscreen and found excellent coverage of the larger facial units such as the forehead, cheeks, chin, and temples. The brow, medial canthus, lateral canthus, and upper and lower eyelids and eyelid margins were infrequently protected with sunscreen during routine application. Our opinion is that patients are unaware that eyelid sunscreen application is important. They may be afraid that the products will sting or cause damage if they get in the eyes. Although some products do sting if they get into the eyes, there is no evidence that sunscreens cause injury to the eyes. The US Food and Drug Administration does not have clear guidelines about applying sunscreens in the periocular area, but in general, mineral blocks are recommended because they have less chance of irritation. Several companies make such products that are designed to be applied to the eyelids.

Limitations of our study included a small sample size and a majority female demographic, which may have affected the results, as women generally are more familiar with the application of lotions to the face. Additionally, the patients were recruited from a tertiary-care clinic and may have had periocular malignancy or may have previously received counseling on the importance of sunscreen use.

Conclusion

Cancer reconstruction of the periocular area is challenging, and even in the best of hands, a patient's quality of life may be negatively affected by postreconstructive appearance or suboptimal function, resulting in ocular exposure. The authors recommend counseling patients on the importance of good sun protection habits, including daily application of sunscreen to the face and periocular region to prevent malignancy in these delicate areas.

UV radiation from sun exposure is a risk factor for most types of skin cancer.¹ Despite comprising only 1% of the body's surface area, the periocular region is the location of approximately 5% to 10% of skin cancers described in one US study.² The efficacy of sunscreen in preventing skin cancer is widely accepted, and the American Academy of Dermatology recommends application of broad-spectrum UVA/UVB sunscreen with a sun protection factor of 30 or higher to help prevent skin cancer.^3-5

RELATED ARTICLE: Sun Protection for Infants: Parent Behaviors and Beliefs

Reducing the risk of skin cancer from sun exposure relies on many factors, including completeness of application. A number of studies have demonstrated incomplete sunscreen application on the hairline, ears, neck, and dorsal feet.^6-8 The purpose of this study was to assess the completeness of facial sunscreen self-application in oculofacial surgery patients using UV photography.

Methods

This single-site, cross-sectional, qualitative study assessed the completeness of facial sunscreen self-application among patients from a single surgeon's (J.A.W.) cosmetic and tertiary-care oculofacial surgery practice at the Duke Eye Center (Durham, North Carolina) between March 2016 and May 2016. Approval from the Duke University institutional review board was obtained, and the research adhered to the tenets of the Declaration of Helsinki and complied with the Health Insurance Portability and Accountability Act. Informed consent was obtained from all patients, and patients could elect to provide specific written consent for publication of photographs in scientific presentations and publications. Patients younger than 18 years of age; those with known sensitivity to sunscreen or its ingredients; and those with an active lesion, rash, or open wound were excluded from the study.

After obtaining informed consent, patients were photographed using a camera with a UV lens in natural outdoor lighting, first without sunscreen and again after self-application of a sunscreen of their choosing using their routine application technique. Completeness of sunscreen application was graded independently by 3 oculofacial surgeons (N.A.L., J.L., J.A.W.) as complete, partial, none, or cannot determine for 15 facial regions. The majority response was used for analysis.

Results

Forty-four patients were enrolled in the study. Six patients were disqualified due to use of mineral-based formulations (zinc oxide and/or titanium dioxide), as these sunscreens could not be visualized using UV photography. The age range of the remaining 38 patients was 28 to 74 years; 26% (10/38) were men and 74% (28/38) were women.

Complete sunscreen application was most frequently performed on the cheeks (97% [37/38]), chin (95% [36/38]), forehead (92% [35/38]), and temples (92% [35/38]). Complete absence of sunscreen coverage was most common on the lower eyelid margin (84% [32/38]), upper eyelid margin (82% [31/38]), medial canthus (71% 27/38]), and upper eyelid (66% [25/38])(Table)(Figure).

Comment

UV radiation-related skin cancers frequently occur in the periocular area, presumably because it is a frequent site of UV exposure. Clothing, sunglasses, and hats can be used to aid in protection from UV radiation, but these products are only regulated by the US Food and Drug Administration if the product claims to prevent skin cancer. Sunscreen is a proven method of protection from UV radiation and the prevention of skin cancer but must be properly applied for it to be effective.^1,2,5,6 Incomplete sunscreen application has been demonstrated in numerous studies. Lademann et al7 studied sunscreen application among 60 beachgoers in Germany and found they typically missed the hairline, ears, and dorsal feet. In a study of 10 women with photosensitivity in England who were asked to apply sunscreen in their routine manner, Azurdia et al⁶ found the posterior neck, lateral neck, temples, and ears, respectively, were the most frequently missed sites. Yang et al⁸ assessed sunscreen application in 39 dermatologists and 41 photosensitive patients in China and found the neck, ears, dorsal hands, hairline, temples, and perioral region, respectively, were most commonly left unprotected.

Our study investigated detailed facial self-application of sunscreen and found excellent coverage of the larger facial units such as the forehead, cheeks, chin, and temples. The brow, medial canthus, lateral canthus, and upper and lower eyelids and eyelid margins were infrequently protected with sunscreen during routine application. Our opinion is that patients are unaware that eyelid sunscreen application is important. They may be afraid that the products will sting or cause damage if they get in the eyes. Although some products do sting if they get into the eyes, there is no evidence that sunscreens cause injury to the eyes. The US Food and Drug Administration does not have clear guidelines about applying sunscreens in the periocular area, but in general, mineral blocks are recommended because they have less chance of irritation. Several companies make such products that are designed to be applied to the eyelids.

Limitations of our study included a small sample size and a majority female demographic, which may have affected the results, as women generally are more familiar with the application of lotions to the face. Additionally, the patients were recruited from a tertiary-care clinic and may have had periocular malignancy or may have previously received counseling on the importance of sunscreen use.

Conclusion

Cancer reconstruction of the periocular area is challenging, and even in the best of hands, a patient's quality of life may be negatively affected by postreconstructive appearance or suboptimal function, resulting in ocular exposure. The authors recommend counseling patients on the importance of good sun protection habits, including daily application of sunscreen to the face and periocular region to prevent malignancy in these delicate areas.

Rejuvenation of the periocular area is in high demand among patients who want to look and feel their best. Physicians should understand the complicated anatomy surrounding the eyes before attempting to inject this area with facial fillers, both to understand the aging process and to minimize treatment complications.

Basic Oculoplastic and Orbital Anatomy

The injector should understand the anatomy of the periocular muscles, the orbital osteology, and the secretory and lacrimal system, in addition to the fat, ligaments, and vascular anatomy in this area.¹

The eyes are surrounded by fat compartments that provide glide planes for the motion of the eyelids and globe. There are 2 upper eyelid fat-pads—nasal and central [preaponeurotic])—in the upper lid, leaving room for the lacrimal gland laterally. There are 3 fat compartments—nasal, central, and lateral—in the lower eyelid. The nasal and central compartments are separated by the inferior oblique muscle, which elevates and extorts the eye. The orbital septum holds the fat-pads in place in the orbit. The brow fat-pad is the retro-orbicularis oculi fat-pad (ROOF). There are fat compartments that lie in the subcutaneous space along the entire forehead and in the temple. The suborbicularis oculi fat-pad (SOOF) lies over the malar eminence. Superficial and deep submuscular fat compartments of the face have been described.² Deep fat compartments also have been examined on computed tomography.³

Orbital circulation comes from the internal carotid artery and anastomoses with the supply from the external carotid artery to supply the orbit. The first branch off of the carotid artery is the ophthalmic artery, and the first branch off of the ophthalmic artery is the central retinal artery that enters the optic nerve sheath 1 cm behind the globe to supply the retina. The supraorbital and supratrochlear arteries branch off of the ophthalmic artery and supply the forehead. The supraorbital artery runs through the supraorbital notch (foramen in 8%)¹ and can usually be palpated with one’s finger. There are 15 to 20 short posterior ciliary arteries leading to the choroid, 2 long posterior ciliary arteries to the iris circle, and 7 anterior ciliary arteries to the extraocular muscles. The superior and inferior venous systems drain into the cavernous sinus.⁴

The ligaments are important to signs of facial aging because tissue atrophy occurs along them. The main orbital ligaments are the lateral orbital thickening (known as the LOT) that adheres the eyelids to the lateral orbital rim and the orbitomalar ligament (orbicularis retaining ligament), which is a condensation fibrous tissue that attaches the skin to the inferior orbital rim and orbital septum along the arcus marginalis and defines the superior edge of the SOOF.⁵ The zygomatic ligament not only suspends the zygomaticus major and zygomaticus minor muscles to the malar eminence but there are osseocutaneous attachments that connect the skin over the zygoma’s malar eminence and demarcate the inferior edge of the SOOF.⁶

Periocular Aging

The skin, fat, muscles, and bones change and rotate with aging, and not all orbits age in the same manner. Older patients with dermatochalasis (excess skin fat and muscle) often undergo rejuvenation with blepharoplasty, a brow-lift, and a midface-lift, but many atrophic changes can be improved with facial fillers.^7,8

As adults age, the soft tissue along the ligaments begins to show atrophy, prime signs of aging that are often improved with fillers. Atrophy along the orbitomalar ligament along the infraorbital rim creates a depressed tear trough, which is an early sign of aging. A 3-point grading system reported by Hirmand⁸ describes the severity of progressive hallowing. There also is atrophy along the zygomatic cutaneous ligament that creates the malar hollow. The SOOF appears to be more prominent when these areas above and below show atrophy, which creates the look of an unwanted bag known as a festoon. Additionally, there is atrophy along the superior orbital notch where the ophthalmic branch of the trigeminal nerve (V1) and the supraorbital artery traverse. Soft-tissue atrophy along the supraorbital notch resembles the peak at the top of the letter A, giving the slang term A-frame deformity.

Periocular fat can atrophy, hypertrophy, herniate forward as the septum weakens, or become ptotic. Some patients develop hypertrophy and herniation of the superior and inferior orbital fat-pads, while others develop unwanted atrophy leaving a hollow superior orbit and loss of support to the levator muscle that contributes to eyelid ptosis. The frontalis fat deflates, leaving veins, arteries, and the hypertrophied corrugators unwantedly visible. Loss of subcutaneous fat in the glabella contributes to the formation of frown lines between the brows (also called number 11’s). The ROOF deflates in some patients adding to brow ptosis. Loss of the facial frame occurs when temple fat atrophies.

Skeletal rotation also occurs. Throughout a patient’s life, the skeleton remodels itself via activity of osteoclasts and osteoblasts. Pessa et al^9,10 has described the expansion of the anterior orbital aperture superomedially and inferolaterally as well as maxillary retrusion that results in angular changes of the midface in relation to the orbital rim. Lambros’ algorithm describes the rotational changes of the cranium where the superior orbit protrudes as the maxilla retreats posteriorly.^9-11 The equator of the globe does not change its distance from the ROOF of the orbit, presumably because of its suspension in the orbit by the optic nerve after it passes through the optic canal and trochlea via the superior oblique muscle, but the distance of the inferior equator of the globe to the floor of the orbit increases as the floor of the orbit descends.¹²

Dermal Fillers for Periocular Rejuvenation

Hyaluronic acid (HA) was first pioneered for use in humans in the late 1970s by ophthalmologists for anterior segment surgery.^13-15 Biocompatibility for orthopedic and dermal applications was explored in the early 1990s.¹⁶

At this time, no dermal filler is approved by the US Food and Drug Administration for use in the periorbital area. Some fillers are approved for subdermal areas extending to the preperiosteal plane and can be used in the midface such as HA fillers (eg, Restylane Lyft [Galderma Laboratories, LP]), Juvéderm Voluma XC [Allergan, Inc]), poly-L-lactic acid (PLLA), and calcium hydroxylapatite (CaHA). No dermal fillers are approved for use in the forehead, glabella, or temples. Their use is becoming increasingly popular but is considered off label. In addition, cannulas are not approved for use in these areas. Cannulas may be beneficial in that they are thought to create less bruising and have less chance of entering a vessel than needles, but some injectors prefer needles because they are stiffer and therefore more precise.

The ideal filler for the tear trough, superior sulcus, ROOF, over the orbitomalar ligament, forehead, and glabella is one that is somewhat moldable but does not migrate, is not hydrophilic, is smooth to inject, and is reversible should there be any complications. No single filler fits this ideal description, but HAs typically are the first choice.

In vitro studies to determine the stiffness (G') and the ability to flow (viscosity) have been performed.^17,18 Calcium hydroxylapatite has the most stiffness, while Belotero Balance (Merz Aesthetics) and Juvéderm Ultra XC (Allergan, Inc) are more soft¹⁷ (Table). These guidelines are important but may not correlate directly with how the fillers behave in vivo as demonstrated in animal models.¹⁸

Periocular Injection Considerations

An experienced injector is one who has developed not only an artistic eye for the face and excellent sense of anatomy but also has a sensitive ability to predict the filler-tissue interaction based on tactile feedback dependent on 3 main qualities: (1) stiffness and viscosity of the filler, (2) gauge of the needle or cannula, and (3) depth of the needle in the tissue. Periocular injections of dermal fillers can be delivered with needles or cannulas, diluted or undiluted. Smaller-gauge needles require more force than larger-gauge needles and cannulas that flow more freely. A needle in the dense dermis will require more force than one placed in the loose subcutaneous space.

The tear trough is generally preferable to fill with a mid-level G' HA filler that is less apt to migrate. A neutral gaze during the injection is preferred because closing or moving the eyes can distort the position of the inferior orbital fat-pads (Figure 1). A needle or cannula can be used, diluted or undiluted. The tear trough can be filled with the injection directed horizontally or vertically via a fanning technique. If needles are used, the skin should be stretched to view the 3 to 5 vertical veins and then the needle should be advanced beneath them to avoid bruising. Avoidance of hydrophilic fillers in the tear trough is important to avoid edema. The superior sulcus can be filled both anteriorly and posteriorly to the septum, which is a highly advanced injection for experienced injectors because of the proximity to the supratrochlear and supraorbital arteries as well as the superior ophthalmic vein (Figure 2). Sharp creases such as deep lateral periocular rhytides known as crow’s-feet are nicely filled with intradermal HAs with a low G'.

Image courtesy of Julie A. Woodward, MD.

Adding volume to the midface is important because it is the continuum of the lower eyelid. Fillers can be injected into multiple levels in this area: deep (to act as pillars to lift the malar eminence and replace bone that has rotated and soft tissue that has become atrophic or descended) and subcutaneous (to efface soft tissue along the zygomatic cutaneous ligament). Higher G' HA fillers and CaHA often are used in the midface along with PLLA. Facial framing of the temples, lateral cheeks, and preauricular area is often accomplished with PLLA but also can be done with mid to high G' HA fillers or CaHA. A cannula may be used to undermine and break apart the zygomatic cutaneous ligament’s cutaneous attachments prior to delivery of the filler in the subcutaneous plane.²⁶ If not done, filler may track away from the hollow area where the ligament is attached and instead move to adjacent areas that will accentuate the hollow and make it look worse.

The temples and lateral face often are filled with PLLA for framing. Mid or high G' HA fillers and CaHA also are used in the temples both beneath the temporalis muscle and also above the deep temporalis fascia or sometimes in the subcutaneous plane.²⁷

Prevention and Management of Periocular Complications

Blindness is the most devastating periocular complication of facial fillers, which is caused by retrograde arterial embolization followed by anterograde flow into the ophthalmic then central retinal arteries. Injectables that have caused blindness include (in descending order of frequency) fat, HA, collagen, paraffin, polymethyl methacrylate, silicone, PLLA, CaHA, polyacrylamide hydrogel, and micronized acellular dermal matrix. Of the 98 cases of blindness from periocular complications from dermal fillers reported in the world literature, the order of affected sites include the glabella (38 cases), nose (25), nasolabial folds (13), superior forehead (12), infraorbital rim (6), temples (1), malar area (1), lip (1), and chin (1). Prevention includes avoidance of danger zone arteries including the supratrochlear, supraorbital, dorsal nasal, angular, infraorbital, zygomaticofacial and zygomaticotemporal arteries.²⁸

Avoiding the average critical volume of 0.84 in any single aliquot dispensed is key to avoid filling of these periocular arteries to the critical bifurcation point that can result in anterograde flow into the eye (Freudenthal Nicolau syndrome). The smallest supratrochlear artery’s volume in this study was 0.04 cc, so aliquots that do not exceed 0.03 cc are ideal.^29,30

The injector should always be thinking about the anatomy of the danger zones (eg, infratrochlear and supratrochlear arteries, supraorbital artery, frontal branch of the superficial temporal artery, lacrimal artery, dorsal nasal artery, infraorbital artery, angular artery, zygomaticofacial artery, zygomaticotemporal artery)(Figure 3).

Image courtesy of Julie A. Woodward, MD.

Conclusion

In summary, periocular injections of facial fillers are useful tools for rejuvenation of the upper face when used with great caution and respect for anatomy.

Rejuvenation of the periocular area is in high demand among patients who want to look and feel their best. Physicians should understand the complicated anatomy surrounding the eyes before attempting to inject this area with facial fillers, both to understand the aging process and to minimize treatment complications.

Basic Oculoplastic and Orbital Anatomy

The injector should understand the anatomy of the periocular muscles, the orbital osteology, and the secretory and lacrimal system, in addition to the fat, ligaments, and vascular anatomy in this area.¹

The eyes are surrounded by fat compartments that provide glide planes for the motion of the eyelids and globe. There are 2 upper eyelid fat-pads—nasal and central [preaponeurotic])—in the upper lid, leaving room for the lacrimal gland laterally. There are 3 fat compartments—nasal, central, and lateral—in the lower eyelid. The nasal and central compartments are separated by the inferior oblique muscle, which elevates and extorts the eye. The orbital septum holds the fat-pads in place in the orbit. The brow fat-pad is the retro-orbicularis oculi fat-pad (ROOF). There are fat compartments that lie in the subcutaneous space along the entire forehead and in the temple. The suborbicularis oculi fat-pad (SOOF) lies over the malar eminence. Superficial and deep submuscular fat compartments of the face have been described.² Deep fat compartments also have been examined on computed tomography.³

Orbital circulation comes from the internal carotid artery and anastomoses with the supply from the external carotid artery to supply the orbit. The first branch off of the carotid artery is the ophthalmic artery, and the first branch off of the ophthalmic artery is the central retinal artery that enters the optic nerve sheath 1 cm behind the globe to supply the retina. The supraorbital and supratrochlear arteries branch off of the ophthalmic artery and supply the forehead. The supraorbital artery runs through the supraorbital notch (foramen in 8%)¹ and can usually be palpated with one’s finger. There are 15 to 20 short posterior ciliary arteries leading to the choroid, 2 long posterior ciliary arteries to the iris circle, and 7 anterior ciliary arteries to the extraocular muscles. The superior and inferior venous systems drain into the cavernous sinus.⁴

The ligaments are important to signs of facial aging because tissue atrophy occurs along them. The main orbital ligaments are the lateral orbital thickening (known as the LOT) that adheres the eyelids to the lateral orbital rim and the orbitomalar ligament (orbicularis retaining ligament), which is a condensation fibrous tissue that attaches the skin to the inferior orbital rim and orbital septum along the arcus marginalis and defines the superior edge of the SOOF.⁵ The zygomatic ligament not only suspends the zygomaticus major and zygomaticus minor muscles to the malar eminence but there are osseocutaneous attachments that connect the skin over the zygoma’s malar eminence and demarcate the inferior edge of the SOOF.⁶

Periocular Aging

The skin, fat, muscles, and bones change and rotate with aging, and not all orbits age in the same manner. Older patients with dermatochalasis (excess skin fat and muscle) often undergo rejuvenation with blepharoplasty, a brow-lift, and a midface-lift, but many atrophic changes can be improved with facial fillers.^7,8

As adults age, the soft tissue along the ligaments begins to show atrophy, prime signs of aging that are often improved with fillers. Atrophy along the orbitomalar ligament along the infraorbital rim creates a depressed tear trough, which is an early sign of aging. A 3-point grading system reported by Hirmand⁸ describes the severity of progressive hallowing. There also is atrophy along the zygomatic cutaneous ligament that creates the malar hollow. The SOOF appears to be more prominent when these areas above and below show atrophy, which creates the look of an unwanted bag known as a festoon. Additionally, there is atrophy along the superior orbital notch where the ophthalmic branch of the trigeminal nerve (V1) and the supraorbital artery traverse. Soft-tissue atrophy along the supraorbital notch resembles the peak at the top of the letter A, giving the slang term A-frame deformity.

Periocular fat can atrophy, hypertrophy, herniate forward as the septum weakens, or become ptotic. Some patients develop hypertrophy and herniation of the superior and inferior orbital fat-pads, while others develop unwanted atrophy leaving a hollow superior orbit and loss of support to the levator muscle that contributes to eyelid ptosis. The frontalis fat deflates, leaving veins, arteries, and the hypertrophied corrugators unwantedly visible. Loss of subcutaneous fat in the glabella contributes to the formation of frown lines between the brows (also called number 11’s). The ROOF deflates in some patients adding to brow ptosis. Loss of the facial frame occurs when temple fat atrophies.

Skeletal rotation also occurs. Throughout a patient’s life, the skeleton remodels itself via activity of osteoclasts and osteoblasts. Pessa et al^9,10 has described the expansion of the anterior orbital aperture superomedially and inferolaterally as well as maxillary retrusion that results in angular changes of the midface in relation to the orbital rim. Lambros’ algorithm describes the rotational changes of the cranium where the superior orbit protrudes as the maxilla retreats posteriorly.^9-11 The equator of the globe does not change its distance from the ROOF of the orbit, presumably because of its suspension in the orbit by the optic nerve after it passes through the optic canal and trochlea via the superior oblique muscle, but the distance of the inferior equator of the globe to the floor of the orbit increases as the floor of the orbit descends.¹²

Dermal Fillers for Periocular Rejuvenation

Hyaluronic acid (HA) was first pioneered for use in humans in the late 1970s by ophthalmologists for anterior segment surgery.^13-15 Biocompatibility for orthopedic and dermal applications was explored in the early 1990s.¹⁶

At this time, no dermal filler is approved by the US Food and Drug Administration for use in the periorbital area. Some fillers are approved for subdermal areas extending to the preperiosteal plane and can be used in the midface such as HA fillers (eg, Restylane Lyft [Galderma Laboratories, LP]), Juvéderm Voluma XC [Allergan, Inc]), poly-L-lactic acid (PLLA), and calcium hydroxylapatite (CaHA). No dermal fillers are approved for use in the forehead, glabella, or temples. Their use is becoming increasingly popular but is considered off label. In addition, cannulas are not approved for use in these areas. Cannulas may be beneficial in that they are thought to create less bruising and have less chance of entering a vessel than needles, but some injectors prefer needles because they are stiffer and therefore more precise.

The ideal filler for the tear trough, superior sulcus, ROOF, over the orbitomalar ligament, forehead, and glabella is one that is somewhat moldable but does not migrate, is not hydrophilic, is smooth to inject, and is reversible should there be any complications. No single filler fits this ideal description, but HAs typically are the first choice.

In vitro studies to determine the stiffness (G') and the ability to flow (viscosity) have been performed.^17,18 Calcium hydroxylapatite has the most stiffness, while Belotero Balance (Merz Aesthetics) and Juvéderm Ultra XC (Allergan, Inc) are more soft¹⁷ (Table). These guidelines are important but may not correlate directly with how the fillers behave in vivo as demonstrated in animal models.¹⁸

Periocular Injection Considerations

An experienced injector is one who has developed not only an artistic eye for the face and excellent sense of anatomy but also has a sensitive ability to predict the filler-tissue interaction based on tactile feedback dependent on 3 main qualities: (1) stiffness and viscosity of the filler, (2) gauge of the needle or cannula, and (3) depth of the needle in the tissue. Periocular injections of dermal fillers can be delivered with needles or cannulas, diluted or undiluted. Smaller-gauge needles require more force than larger-gauge needles and cannulas that flow more freely. A needle in the dense dermis will require more force than one placed in the loose subcutaneous space.

The tear trough is generally preferable to fill with a mid-level G' HA filler that is less apt to migrate. A neutral gaze during the injection is preferred because closing or moving the eyes can distort the position of the inferior orbital fat-pads (Figure 1). A needle or cannula can be used, diluted or undiluted. The tear trough can be filled with the injection directed horizontally or vertically via a fanning technique. If needles are used, the skin should be stretched to view the 3 to 5 vertical veins and then the needle should be advanced beneath them to avoid bruising. Avoidance of hydrophilic fillers in the tear trough is important to avoid edema. The superior sulcus can be filled both anteriorly and posteriorly to the septum, which is a highly advanced injection for experienced injectors because of the proximity to the supratrochlear and supraorbital arteries as well as the superior ophthalmic vein (Figure 2). Sharp creases such as deep lateral periocular rhytides known as crow’s-feet are nicely filled with intradermal HAs with a low G'.

Image courtesy of Julie A. Woodward, MD.

Adding volume to the midface is important because it is the continuum of the lower eyelid. Fillers can be injected into multiple levels in this area: deep (to act as pillars to lift the malar eminence and replace bone that has rotated and soft tissue that has become atrophic or descended) and subcutaneous (to efface soft tissue along the zygomatic cutaneous ligament). Higher G' HA fillers and CaHA often are used in the midface along with PLLA. Facial framing of the temples, lateral cheeks, and preauricular area is often accomplished with PLLA but also can be done with mid to high G' HA fillers or CaHA. A cannula may be used to undermine and break apart the zygomatic cutaneous ligament’s cutaneous attachments prior to delivery of the filler in the subcutaneous plane.²⁶ If not done, filler may track away from the hollow area where the ligament is attached and instead move to adjacent areas that will accentuate the hollow and make it look worse.

The temples and lateral face often are filled with PLLA for framing. Mid or high G' HA fillers and CaHA also are used in the temples both beneath the temporalis muscle and also above the deep temporalis fascia or sometimes in the subcutaneous plane.²⁷

Prevention and Management of Periocular Complications

Blindness is the most devastating periocular complication of facial fillers, which is caused by retrograde arterial embolization followed by anterograde flow into the ophthalmic then central retinal arteries. Injectables that have caused blindness include (in descending order of frequency) fat, HA, collagen, paraffin, polymethyl methacrylate, silicone, PLLA, CaHA, polyacrylamide hydrogel, and micronized acellular dermal matrix. Of the 98 cases of blindness from periocular complications from dermal fillers reported in the world literature, the order of affected sites include the glabella (38 cases), nose (25), nasolabial folds (13), superior forehead (12), infraorbital rim (6), temples (1), malar area (1), lip (1), and chin (1). Prevention includes avoidance of danger zone arteries including the supratrochlear, supraorbital, dorsal nasal, angular, infraorbital, zygomaticofacial and zygomaticotemporal arteries.²⁸

Avoiding the average critical volume of 0.84 in any single aliquot dispensed is key to avoid filling of these periocular arteries to the critical bifurcation point that can result in anterograde flow into the eye (Freudenthal Nicolau syndrome). The smallest supratrochlear artery’s volume in this study was 0.04 cc, so aliquots that do not exceed 0.03 cc are ideal.^29,30

The injector should always be thinking about the anatomy of the danger zones (eg, infratrochlear and supratrochlear arteries, supraorbital artery, frontal branch of the superficial temporal artery, lacrimal artery, dorsal nasal artery, infraorbital artery, angular artery, zygomaticofacial artery, zygomaticotemporal artery)(Figure 3).

Image courtesy of Julie A. Woodward, MD.

Conclusion

In summary, periocular injections of facial fillers are useful tools for rejuvenation of the upper face when used with great caution and respect for anatomy.

Rejuvenation of the periocular area is in high demand among patients who want to look and feel their best. Physicians should understand the complicated anatomy surrounding the eyes before attempting to inject this area with facial fillers, both to understand the aging process and to minimize treatment complications.

Basic Oculoplastic and Orbital Anatomy

The injector should understand the anatomy of the periocular muscles, the orbital osteology, and the secretory and lacrimal system, in addition to the fat, ligaments, and vascular anatomy in this area.¹

The eyes are surrounded by fat compartments that provide glide planes for the motion of the eyelids and globe. There are 2 upper eyelid fat-pads—nasal and central [preaponeurotic])—in the upper lid, leaving room for the lacrimal gland laterally. There are 3 fat compartments—nasal, central, and lateral—in the lower eyelid. The nasal and central compartments are separated by the inferior oblique muscle, which elevates and extorts the eye. The orbital septum holds the fat-pads in place in the orbit. The brow fat-pad is the retro-orbicularis oculi fat-pad (ROOF). There are fat compartments that lie in the subcutaneous space along the entire forehead and in the temple. The suborbicularis oculi fat-pad (SOOF) lies over the malar eminence. Superficial and deep submuscular fat compartments of the face have been described.² Deep fat compartments also have been examined on computed tomography.³

Orbital circulation comes from the internal carotid artery and anastomoses with the supply from the external carotid artery to supply the orbit. The first branch off of the carotid artery is the ophthalmic artery, and the first branch off of the ophthalmic artery is the central retinal artery that enters the optic nerve sheath 1 cm behind the globe to supply the retina. The supraorbital and supratrochlear arteries branch off of the ophthalmic artery and supply the forehead. The supraorbital artery runs through the supraorbital notch (foramen in 8%)¹ and can usually be palpated with one’s finger. There are 15 to 20 short posterior ciliary arteries leading to the choroid, 2 long posterior ciliary arteries to the iris circle, and 7 anterior ciliary arteries to the extraocular muscles. The superior and inferior venous systems drain into the cavernous sinus.⁴

The ligaments are important to signs of facial aging because tissue atrophy occurs along them. The main orbital ligaments are the lateral orbital thickening (known as the LOT) that adheres the eyelids to the lateral orbital rim and the orbitomalar ligament (orbicularis retaining ligament), which is a condensation fibrous tissue that attaches the skin to the inferior orbital rim and orbital septum along the arcus marginalis and defines the superior edge of the SOOF.⁵ The zygomatic ligament not only suspends the zygomaticus major and zygomaticus minor muscles to the malar eminence but there are osseocutaneous attachments that connect the skin over the zygoma’s malar eminence and demarcate the inferior edge of the SOOF.⁶

Periocular Aging

The skin, fat, muscles, and bones change and rotate with aging, and not all orbits age in the same manner. Older patients with dermatochalasis (excess skin fat and muscle) often undergo rejuvenation with blepharoplasty, a brow-lift, and a midface-lift, but many atrophic changes can be improved with facial fillers.^7,8

As adults age, the soft tissue along the ligaments begins to show atrophy, prime signs of aging that are often improved with fillers. Atrophy along the orbitomalar ligament along the infraorbital rim creates a depressed tear trough, which is an early sign of aging. A 3-point grading system reported by Hirmand⁸ describes the severity of progressive hallowing. There also is atrophy along the zygomatic cutaneous ligament that creates the malar hollow. The SOOF appears to be more prominent when these areas above and below show atrophy, which creates the look of an unwanted bag known as a festoon. Additionally, there is atrophy along the superior orbital notch where the ophthalmic branch of the trigeminal nerve (V1) and the supraorbital artery traverse. Soft-tissue atrophy along the supraorbital notch resembles the peak at the top of the letter A, giving the slang term A-frame deformity.

Periocular fat can atrophy, hypertrophy, herniate forward as the septum weakens, or become ptotic. Some patients develop hypertrophy and herniation of the superior and inferior orbital fat-pads, while others develop unwanted atrophy leaving a hollow superior orbit and loss of support to the levator muscle that contributes to eyelid ptosis. The frontalis fat deflates, leaving veins, arteries, and the hypertrophied corrugators unwantedly visible. Loss of subcutaneous fat in the glabella contributes to the formation of frown lines between the brows (also called number 11’s). The ROOF deflates in some patients adding to brow ptosis. Loss of the facial frame occurs when temple fat atrophies.

Skeletal rotation also occurs. Throughout a patient’s life, the skeleton remodels itself via activity of osteoclasts and osteoblasts. Pessa et al^9,10 has described the expansion of the anterior orbital aperture superomedially and inferolaterally as well as maxillary retrusion that results in angular changes of the midface in relation to the orbital rim. Lambros’ algorithm describes the rotational changes of the cranium where the superior orbit protrudes as the maxilla retreats posteriorly.^9-11 The equator of the globe does not change its distance from the ROOF of the orbit, presumably because of its suspension in the orbit by the optic nerve after it passes through the optic canal and trochlea via the superior oblique muscle, but the distance of the inferior equator of the globe to the floor of the orbit increases as the floor of the orbit descends.¹²

Dermal Fillers for Periocular Rejuvenation

Hyaluronic acid (HA) was first pioneered for use in humans in the late 1970s by ophthalmologists for anterior segment surgery.^13-15 Biocompatibility for orthopedic and dermal applications was explored in the early 1990s.¹⁶

At this time, no dermal filler is approved by the US Food and Drug Administration for use in the periorbital area. Some fillers are approved for subdermal areas extending to the preperiosteal plane and can be used in the midface such as HA fillers (eg, Restylane Lyft [Galderma Laboratories, LP]), Juvéderm Voluma XC [Allergan, Inc]), poly-L-lactic acid (PLLA), and calcium hydroxylapatite (CaHA). No dermal fillers are approved for use in the forehead, glabella, or temples. Their use is becoming increasingly popular but is considered off label. In addition, cannulas are not approved for use in these areas. Cannulas may be beneficial in that they are thought to create less bruising and have less chance of entering a vessel than needles, but some injectors prefer needles because they are stiffer and therefore more precise.

The ideal filler for the tear trough, superior sulcus, ROOF, over the orbitomalar ligament, forehead, and glabella is one that is somewhat moldable but does not migrate, is not hydrophilic, is smooth to inject, and is reversible should there be any complications. No single filler fits this ideal description, but HAs typically are the first choice.

In vitro studies to determine the stiffness (G') and the ability to flow (viscosity) have been performed.^17,18 Calcium hydroxylapatite has the most stiffness, while Belotero Balance (Merz Aesthetics) and Juvéderm Ultra XC (Allergan, Inc) are more soft¹⁷ (Table). These guidelines are important but may not correlate directly with how the fillers behave in vivo as demonstrated in animal models.¹⁸

Periocular Injection Considerations

An experienced injector is one who has developed not only an artistic eye for the face and excellent sense of anatomy but also has a sensitive ability to predict the filler-tissue interaction based on tactile feedback dependent on 3 main qualities: (1) stiffness and viscosity of the filler, (2) gauge of the needle or cannula, and (3) depth of the needle in the tissue. Periocular injections of dermal fillers can be delivered with needles or cannulas, diluted or undiluted. Smaller-gauge needles require more force than larger-gauge needles and cannulas that flow more freely. A needle in the dense dermis will require more force than one placed in the loose subcutaneous space.

The tear trough is generally preferable to fill with a mid-level G' HA filler that is less apt to migrate. A neutral gaze during the injection is preferred because closing or moving the eyes can distort the position of the inferior orbital fat-pads (Figure 1). A needle or cannula can be used, diluted or undiluted. The tear trough can be filled with the injection directed horizontally or vertically via a fanning technique. If needles are used, the skin should be stretched to view the 3 to 5 vertical veins and then the needle should be advanced beneath them to avoid bruising. Avoidance of hydrophilic fillers in the tear trough is important to avoid edema. The superior sulcus can be filled both anteriorly and posteriorly to the septum, which is a highly advanced injection for experienced injectors because of the proximity to the supratrochlear and supraorbital arteries as well as the superior ophthalmic vein (Figure 2). Sharp creases such as deep lateral periocular rhytides known as crow’s-feet are nicely filled with intradermal HAs with a low G'.

Image courtesy of Julie A. Woodward, MD.

Adding volume to the midface is important because it is the continuum of the lower eyelid. Fillers can be injected into multiple levels in this area: deep (to act as pillars to lift the malar eminence and replace bone that has rotated and soft tissue that has become atrophic or descended) and subcutaneous (to efface soft tissue along the zygomatic cutaneous ligament). Higher G' HA fillers and CaHA often are used in the midface along with PLLA. Facial framing of the temples, lateral cheeks, and preauricular area is often accomplished with PLLA but also can be done with mid to high G' HA fillers or CaHA. A cannula may be used to undermine and break apart the zygomatic cutaneous ligament’s cutaneous attachments prior to delivery of the filler in the subcutaneous plane.²⁶ If not done, filler may track away from the hollow area where the ligament is attached and instead move to adjacent areas that will accentuate the hollow and make it look worse.

The temples and lateral face often are filled with PLLA for framing. Mid or high G' HA fillers and CaHA also are used in the temples both beneath the temporalis muscle and also above the deep temporalis fascia or sometimes in the subcutaneous plane.²⁷

Prevention and Management of Periocular Complications

Blindness is the most devastating periocular complication of facial fillers, which is caused by retrograde arterial embolization followed by anterograde flow into the ophthalmic then central retinal arteries. Injectables that have caused blindness include (in descending order of frequency) fat, HA, collagen, paraffin, polymethyl methacrylate, silicone, PLLA, CaHA, polyacrylamide hydrogel, and micronized acellular dermal matrix. Of the 98 cases of blindness from periocular complications from dermal fillers reported in the world literature, the order of affected sites include the glabella (38 cases), nose (25), nasolabial folds (13), superior forehead (12), infraorbital rim (6), temples (1), malar area (1), lip (1), and chin (1). Prevention includes avoidance of danger zone arteries including the supratrochlear, supraorbital, dorsal nasal, angular, infraorbital, zygomaticofacial and zygomaticotemporal arteries.²⁸

Avoiding the average critical volume of 0.84 in any single aliquot dispensed is key to avoid filling of these periocular arteries to the critical bifurcation point that can result in anterograde flow into the eye (Freudenthal Nicolau syndrome). The smallest supratrochlear artery’s volume in this study was 0.04 cc, so aliquots that do not exceed 0.03 cc are ideal.^29,30

The injector should always be thinking about the anatomy of the danger zones (eg, infratrochlear and supratrochlear arteries, supraorbital artery, frontal branch of the superficial temporal artery, lacrimal artery, dorsal nasal artery, infraorbital artery, angular artery, zygomaticofacial artery, zygomaticotemporal artery)(Figure 3).

Image courtesy of Julie A. Woodward, MD.

Conclusion

In summary, periocular injections of facial fillers are useful tools for rejuvenation of the upper face when used with great caution and respect for anatomy.