Article Type
Changed
Thu, 01/10/2019 - 13:27
Display Headline
Genetic Pathways, Part 2

Review the PDF of the fact sheet on genetic pathways
with board-relevant, easy-to-review material. This fact sheet is the second of 2 parts covering a wide spectrum of tumor suppressor pathways from folliculin to neurofibromin 1. 

After, test your knowledge by answering the 5 practice questions.

Practice Questions

1. A 6-month-old male infant presented to your dermatology clinic with an ash-leaf macule on the right back. What is the most common gene defect seen in this condition?

a. tuberin

b. merlin

c. neurofibromin

d. smoothened

e. hamartin

 

 

2. Bilateral acoustic neuromas are associated with what gene mutation?

a. NF1 (neurofibromin 1)

b. NF2 (neurofibromin 2)

c. PTCH1 (patched 1)

d. TSC1 (tuberous sclerosis 1)

e. TSC2 (tuberous sclerosis 2)

 

 

3. Which of the following would least likely be seen in neurofibromatosis types 1 or 2?

a. angiofibromas

b. café au lait macules

c. gliomas

d. Lisch nodules

e. neurofibromas

 

 

4. What protein is the patched 1 gene a receptor for?

a. fused

b. glioma-associated oncogene

c. smoothened

d. sonic hedgehog

e. suppressor of fused

 

 

5. A 20-year-old woman presented to your dermatology clinic with a history of numerous basal cell carcinomas. On physical examination, it is noted that she has numerous palmar pits. What finding could you find from radiograph of the head?

a. calcification of the dura

b. calcifications of the temporal lobe

c. cysts of the mandible

d. thickening of the corpus callosum

e. tumor of the cerebellum

 

 

1. A 6-month-old male infant presented to your dermatology clinic with an ash-leaf macule on the right back. What is the most common gene defect seen in this condition?

a. tuberin

b. merlin

c. neurofibromin

d. smoothened

e. hamartin

 

2. Bilateral acoustic neuromas are associated with what gene mutation?

a. NF1 (neurofibromin 1)

b. NF2 (neurofibromin 2)

c. PTCH1 (patched 1)

d. TSC1 (tuberous sclerosis 1)

e. TSC2 (tuberous sclerosis 2)

 

3. Which of the following would least likely be seen in neurofibromatosis types 1 or 2?

a. angiofibromas

b. café au lait macules

c. gliomas

d. Lisch nodules

e. neurofibromas

 

4. What protein is the patched 1 gene a receptor for?

a. fused

b. glioma-associated oncogene

c. smoothened

d. sonic hedgehog

e. suppressor of fused

 

5. A 20-year-old woman presented to your dermatology clinic with a history of numerous basal cell carcinomas. On physical examination, it is noted that she has numerous palmar pits. What finding could you find from radiograph of the head?

a. calcification of the dura

b. calcifications of the temporal lobe

c. cysts of the mandible

d. thickening of the corpus callosum

e. tumor of the cerebellum

Article PDF
Author and Disclosure Information

Dr. Daniel is from is from the Department of Dermatology, Wake Forest University, Winston-Salem, North Carolina.

The author reports no conflict of interest.

Publications
Legacy Keywords
Gardner syndrome, genes, folliculin, von Recklinghausen disease, Neurofibromatosis, Gorlin syndrome, genetic pathways
Sections
Author and Disclosure Information

Dr. Daniel is from is from the Department of Dermatology, Wake Forest University, Winston-Salem, North Carolina.

The author reports no conflict of interest.

Author and Disclosure Information

Dr. Daniel is from is from the Department of Dermatology, Wake Forest University, Winston-Salem, North Carolina.

The author reports no conflict of interest.

Article PDF
Article PDF
Related Articles

Review the PDF of the fact sheet on genetic pathways
with board-relevant, easy-to-review material. This fact sheet is the second of 2 parts covering a wide spectrum of tumor suppressor pathways from folliculin to neurofibromin 1. 

After, test your knowledge by answering the 5 practice questions.

Practice Questions

1. A 6-month-old male infant presented to your dermatology clinic with an ash-leaf macule on the right back. What is the most common gene defect seen in this condition?

a. tuberin

b. merlin

c. neurofibromin

d. smoothened

e. hamartin

 

 

2. Bilateral acoustic neuromas are associated with what gene mutation?

a. NF1 (neurofibromin 1)

b. NF2 (neurofibromin 2)

c. PTCH1 (patched 1)

d. TSC1 (tuberous sclerosis 1)

e. TSC2 (tuberous sclerosis 2)

 

 

3. Which of the following would least likely be seen in neurofibromatosis types 1 or 2?

a. angiofibromas

b. café au lait macules

c. gliomas

d. Lisch nodules

e. neurofibromas

 

 

4. What protein is the patched 1 gene a receptor for?

a. fused

b. glioma-associated oncogene

c. smoothened

d. sonic hedgehog

e. suppressor of fused

 

 

5. A 20-year-old woman presented to your dermatology clinic with a history of numerous basal cell carcinomas. On physical examination, it is noted that she has numerous palmar pits. What finding could you find from radiograph of the head?

a. calcification of the dura

b. calcifications of the temporal lobe

c. cysts of the mandible

d. thickening of the corpus callosum

e. tumor of the cerebellum

 

 

1. A 6-month-old male infant presented to your dermatology clinic with an ash-leaf macule on the right back. What is the most common gene defect seen in this condition?

a. tuberin

b. merlin

c. neurofibromin

d. smoothened

e. hamartin

 

2. Bilateral acoustic neuromas are associated with what gene mutation?

a. NF1 (neurofibromin 1)

b. NF2 (neurofibromin 2)

c. PTCH1 (patched 1)

d. TSC1 (tuberous sclerosis 1)

e. TSC2 (tuberous sclerosis 2)

 

3. Which of the following would least likely be seen in neurofibromatosis types 1 or 2?

a. angiofibromas

b. café au lait macules

c. gliomas

d. Lisch nodules

e. neurofibromas

 

4. What protein is the patched 1 gene a receptor for?

a. fused

b. glioma-associated oncogene

c. smoothened

d. sonic hedgehog

e. suppressor of fused

 

5. A 20-year-old woman presented to your dermatology clinic with a history of numerous basal cell carcinomas. On physical examination, it is noted that she has numerous palmar pits. What finding could you find from radiograph of the head?

a. calcification of the dura

b. calcifications of the temporal lobe

c. cysts of the mandible

d. thickening of the corpus callosum

e. tumor of the cerebellum

Review the PDF of the fact sheet on genetic pathways
with board-relevant, easy-to-review material. This fact sheet is the second of 2 parts covering a wide spectrum of tumor suppressor pathways from folliculin to neurofibromin 1. 

After, test your knowledge by answering the 5 practice questions.

Practice Questions

1. A 6-month-old male infant presented to your dermatology clinic with an ash-leaf macule on the right back. What is the most common gene defect seen in this condition?

a. tuberin

b. merlin

c. neurofibromin

d. smoothened

e. hamartin

 

 

2. Bilateral acoustic neuromas are associated with what gene mutation?

a. NF1 (neurofibromin 1)

b. NF2 (neurofibromin 2)

c. PTCH1 (patched 1)

d. TSC1 (tuberous sclerosis 1)

e. TSC2 (tuberous sclerosis 2)

 

 

3. Which of the following would least likely be seen in neurofibromatosis types 1 or 2?

a. angiofibromas

b. café au lait macules

c. gliomas

d. Lisch nodules

e. neurofibromas

 

 

4. What protein is the patched 1 gene a receptor for?

a. fused

b. glioma-associated oncogene

c. smoothened

d. sonic hedgehog

e. suppressor of fused

 

 

5. A 20-year-old woman presented to your dermatology clinic with a history of numerous basal cell carcinomas. On physical examination, it is noted that she has numerous palmar pits. What finding could you find from radiograph of the head?

a. calcification of the dura

b. calcifications of the temporal lobe

c. cysts of the mandible

d. thickening of the corpus callosum

e. tumor of the cerebellum

 

 

1. A 6-month-old male infant presented to your dermatology clinic with an ash-leaf macule on the right back. What is the most common gene defect seen in this condition?

a. tuberin

b. merlin

c. neurofibromin

d. smoothened

e. hamartin

 

2. Bilateral acoustic neuromas are associated with what gene mutation?

a. NF1 (neurofibromin 1)

b. NF2 (neurofibromin 2)

c. PTCH1 (patched 1)

d. TSC1 (tuberous sclerosis 1)

e. TSC2 (tuberous sclerosis 2)

 

3. Which of the following would least likely be seen in neurofibromatosis types 1 or 2?

a. angiofibromas

b. café au lait macules

c. gliomas

d. Lisch nodules

e. neurofibromas

 

4. What protein is the patched 1 gene a receptor for?

a. fused

b. glioma-associated oncogene

c. smoothened

d. sonic hedgehog

e. suppressor of fused

 

5. A 20-year-old woman presented to your dermatology clinic with a history of numerous basal cell carcinomas. On physical examination, it is noted that she has numerous palmar pits. What finding could you find from radiograph of the head?

a. calcification of the dura

b. calcifications of the temporal lobe

c. cysts of the mandible

d. thickening of the corpus callosum

e. tumor of the cerebellum

Publications
Publications
Article Type
Display Headline
Genetic Pathways, Part 2
Display Headline
Genetic Pathways, Part 2
Legacy Keywords
Gardner syndrome, genes, folliculin, von Recklinghausen disease, Neurofibromatosis, Gorlin syndrome, genetic pathways
Legacy Keywords
Gardner syndrome, genes, folliculin, von Recklinghausen disease, Neurofibromatosis, Gorlin syndrome, genetic pathways
Sections
Disallow All Ads
Alternative CME
Article PDF Media