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Key clinical point: Inner nuclear layer (INL) and outer nuclear layer (ONL) measures may be novel biomarkers of neurodegeneration in patients with progressive multiple sclerosis (PMS).
Major finding: Independent of age, PMS vs. relapsing-remitting MS (RRMS) was associated with a faster thinning of peri-papillary retinal nerve fiber layer (β = −0.34%/year; P less than .001), ganglion cell+inner plexiform layer (β = −0.27%/year; P less than .001), INL (β = −0.10%/year; P = .01), and ONL (β = −0.13%/year; P = .01).
Study details: In all, 178 RRMS, 186 PMS, and 66 control participants were followed for a median of 3.7 years; retinal imaging was performed with spectral-domain optical coherence tomography.
Disclosures: This study was funded by the NIH/NINDS, National MS Society, Race to Erase MS, Walters Foundation, and ACTRIMS. The authors declared no conflict of interest.
Citation: Sotirchos ES et al. Ann Neurol. 2020 Apr 13. doi: 10.1002/ana.25738.
Key clinical point: Inner nuclear layer (INL) and outer nuclear layer (ONL) measures may be novel biomarkers of neurodegeneration in patients with progressive multiple sclerosis (PMS).
Major finding: Independent of age, PMS vs. relapsing-remitting MS (RRMS) was associated with a faster thinning of peri-papillary retinal nerve fiber layer (β = −0.34%/year; P less than .001), ganglion cell+inner plexiform layer (β = −0.27%/year; P less than .001), INL (β = −0.10%/year; P = .01), and ONL (β = −0.13%/year; P = .01).
Study details: In all, 178 RRMS, 186 PMS, and 66 control participants were followed for a median of 3.7 years; retinal imaging was performed with spectral-domain optical coherence tomography.
Disclosures: This study was funded by the NIH/NINDS, National MS Society, Race to Erase MS, Walters Foundation, and ACTRIMS. The authors declared no conflict of interest.
Citation: Sotirchos ES et al. Ann Neurol. 2020 Apr 13. doi: 10.1002/ana.25738.
Key clinical point: Inner nuclear layer (INL) and outer nuclear layer (ONL) measures may be novel biomarkers of neurodegeneration in patients with progressive multiple sclerosis (PMS).
Major finding: Independent of age, PMS vs. relapsing-remitting MS (RRMS) was associated with a faster thinning of peri-papillary retinal nerve fiber layer (β = −0.34%/year; P less than .001), ganglion cell+inner plexiform layer (β = −0.27%/year; P less than .001), INL (β = −0.10%/year; P = .01), and ONL (β = −0.13%/year; P = .01).
Study details: In all, 178 RRMS, 186 PMS, and 66 control participants were followed for a median of 3.7 years; retinal imaging was performed with spectral-domain optical coherence tomography.
Disclosures: This study was funded by the NIH/NINDS, National MS Society, Race to Erase MS, Walters Foundation, and ACTRIMS. The authors declared no conflict of interest.
Citation: Sotirchos ES et al. Ann Neurol. 2020 Apr 13. doi: 10.1002/ana.25738.