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PROBABLY NOT. Although certain electrocardiogram (EKG) findings in asymptomatic adults are associated with increased mortality (strength of recommendation [SOR]: A, high-quality cohort studies), no randomized trials demonstrate that any intervention based on abnormal screening EKGs improves outcomes in this group of patients. Comparison to a baseline EKG has a minimal effect on emergency department (ED) management.(SOR: B, 2 prospective studies and one retrospective study).
Evidence summary
The US Pooling Project divided EKG abnormalities into major and minor findings.1 A number of large cohort studies have shown that both major and minor findings are associated with an elevated odds ratio for mortality (TABLE).1-5 However, these studies, completed before the development of modern medical management of acute coronary syndrome and stable coronary artery disease, may no longer estimate mortality accurately. Moreover, no studies have examined the effect of screening EKGs on coronary heart disease (CHD) outcomes.
Neither major nor minor EKG abnormalities linked to higher mortality
A 2012 cohort study—which included Q-waves as major criteria and examined fewer minor abnormalities than previous studies—followed 2192 patients 70 to 79 years of age for 8 years.6 The study enrolled a higher percentage of women and blacks than earlier investigations had.
Major EKG abnormalities predicted an increase in CHD events (hazard ratio [HR]=1.51; 95% confidence interval [CI], 1.20-1.90) as did minor abnormalities (HR=1.35; 95% CI, 1.02-1.81). In contrast to earlier studies, which tended to enroll younger patients, neither type of abnormality was associated with a significantly increased risk of all-cause mortality.6
Including EKG abnormalities in a regression model of traditional risk factors improved stratification (overall net reclassification improvement [NRI]=7.4%; 95% CI, 3.1%-19.0%).6 No low-risk patients were reclassified as high risk and no high-risk patients were reclassified as low risk. Overall, 156 intermediate risk patients were correctly reclassified and an equal number were incorrectly reclassified. Adding EKG abnormalities to the Framingham Risk Score (which hasn’t been validated in adults >75 years) didn’t significantly improve stratification (NRI=5.7%; 95% CI, −0.4% to 11.8%).6
Comparing ED with baseline EKGs has little effect on management
A 1980 retrospective study looked at 236 patients with acute chest pain and no known CHD who were seen in the ED. Comparing routine baseline EKGs obtained before ED presentation for 6 of 41 patients with equivocal EKGs in the ED—including T-wave inversions, nonspecific T-wave and ST-segment abnormalities, and bundle branch blocks—prevented 2 admissions (no EKG change from baseline) and caused 4 unnecessary admissions (EKG changed from baseline with no subsequent evidence of acute coronary syndromes).7
A 1985 prospective study of 84 ED patients, in which treating physicians were given baseline EKGs after committing to an initial disposition plan, showed that the baseline EKG altered the decision to admit or discharge in only one case.8
A 1990 prospective multicenter study of 5673 patients older than 30 years—41% of whom had known CHD—reported that when the current EKG was consistent with ischemia or infarction, a baseline EKG showing the changes to be old (10% of study population) increased the likelihood that the patient would be discharged from the ED to home (26% vs 12%; risk difference=14%; 95% CI, 7%-23%). Unlike previous studies, however, the exact role of the baseline EKG in the admission decision was isolated not by study design but rather by multivariate logistic regression modeling.9
Recommendations
The 2010 American College of Cardiology Foundation/American Heart Association (ACCF/AHA) guideline for assessment of cardiovascular risk in asymptomatic adults states that a resting EKG is probably indicated in patients with diabetes and hypertension and that its usefulness in patients without these conditions isn’t well established.2
The US Preventive Services Task Force recommends against screening EKGs in adults at low risk for CHD events (grade D recommendation).10
1. Sosenko J, Gardner L. Relationship of blood pressure, serum cholesterol, smoking habit, relative weight and ECG abnormalities to incidence of major coronary events: final report of the pooling project. J Chronic Dis. 1978;31:201-306.
2. Greenland P, Alpert J, Beller G, et al. 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2010;56:e50-e103.
3. Sox HC Jr, Garber AM, Littenberg B. The resting electrocardiogram as a screening test. A clinical analysis. Ann Intern Med. 1989;111:489-502.
4. DeBaquer D, De Backer G, Kornitzer M, et al. Prognostic value of ECG findings for total, cardiovascular disease, and coronary heart disease death in men and women. Heart. 1998;80: 570-577.
5. Whinnicup P, Goya W, Marcarlane P, et al. Resting electrocardiogram and risk of coronary heart disease in middle-aged British men. J Cardiovasc Risk. 1995;2:533-543.
6. Auer R, Bauer DC, Marques-Vidal P, et al. Association of major and minor ECG abnormalities with coronary heart disease events. JAMA. 2012;307:1497-1505.
7. Rubenstein LZ, Greenfield S. The baseline ECG in the evaluation of acute cardiac complaints. JAMA. 1980;244:2536-2539.
8. Hoffman JR, Igarashi E. Influence of electrocardiographic findings on admission decisions in patients with acute chest pain. Am J Med. 1985;79:699-707.
9. Lee TH, Cook EF, Weisberg MC, et al. Impact of the availability of a prior electrocardiogram on the triage of the patient with acute chest pain. J Gen Intern Med. 1990;5:381-388.
10. Chou R, Arora B, Dana T, et al. Screening asymptomatic adults with resting or exercise electrocardiography: a review of the evidence for the US Preventive Services Task Force. Ann Intern Med. 2011;155:375-385.
PROBABLY NOT. Although certain electrocardiogram (EKG) findings in asymptomatic adults are associated with increased mortality (strength of recommendation [SOR]: A, high-quality cohort studies), no randomized trials demonstrate that any intervention based on abnormal screening EKGs improves outcomes in this group of patients. Comparison to a baseline EKG has a minimal effect on emergency department (ED) management.(SOR: B, 2 prospective studies and one retrospective study).
Evidence summary
The US Pooling Project divided EKG abnormalities into major and minor findings.1 A number of large cohort studies have shown that both major and minor findings are associated with an elevated odds ratio for mortality (TABLE).1-5 However, these studies, completed before the development of modern medical management of acute coronary syndrome and stable coronary artery disease, may no longer estimate mortality accurately. Moreover, no studies have examined the effect of screening EKGs on coronary heart disease (CHD) outcomes.
Neither major nor minor EKG abnormalities linked to higher mortality
A 2012 cohort study—which included Q-waves as major criteria and examined fewer minor abnormalities than previous studies—followed 2192 patients 70 to 79 years of age for 8 years.6 The study enrolled a higher percentage of women and blacks than earlier investigations had.
Major EKG abnormalities predicted an increase in CHD events (hazard ratio [HR]=1.51; 95% confidence interval [CI], 1.20-1.90) as did minor abnormalities (HR=1.35; 95% CI, 1.02-1.81). In contrast to earlier studies, which tended to enroll younger patients, neither type of abnormality was associated with a significantly increased risk of all-cause mortality.6
Including EKG abnormalities in a regression model of traditional risk factors improved stratification (overall net reclassification improvement [NRI]=7.4%; 95% CI, 3.1%-19.0%).6 No low-risk patients were reclassified as high risk and no high-risk patients were reclassified as low risk. Overall, 156 intermediate risk patients were correctly reclassified and an equal number were incorrectly reclassified. Adding EKG abnormalities to the Framingham Risk Score (which hasn’t been validated in adults >75 years) didn’t significantly improve stratification (NRI=5.7%; 95% CI, −0.4% to 11.8%).6
Comparing ED with baseline EKGs has little effect on management
A 1980 retrospective study looked at 236 patients with acute chest pain and no known CHD who were seen in the ED. Comparing routine baseline EKGs obtained before ED presentation for 6 of 41 patients with equivocal EKGs in the ED—including T-wave inversions, nonspecific T-wave and ST-segment abnormalities, and bundle branch blocks—prevented 2 admissions (no EKG change from baseline) and caused 4 unnecessary admissions (EKG changed from baseline with no subsequent evidence of acute coronary syndromes).7
A 1985 prospective study of 84 ED patients, in which treating physicians were given baseline EKGs after committing to an initial disposition plan, showed that the baseline EKG altered the decision to admit or discharge in only one case.8
A 1990 prospective multicenter study of 5673 patients older than 30 years—41% of whom had known CHD—reported that when the current EKG was consistent with ischemia or infarction, a baseline EKG showing the changes to be old (10% of study population) increased the likelihood that the patient would be discharged from the ED to home (26% vs 12%; risk difference=14%; 95% CI, 7%-23%). Unlike previous studies, however, the exact role of the baseline EKG in the admission decision was isolated not by study design but rather by multivariate logistic regression modeling.9
Recommendations
The 2010 American College of Cardiology Foundation/American Heart Association (ACCF/AHA) guideline for assessment of cardiovascular risk in asymptomatic adults states that a resting EKG is probably indicated in patients with diabetes and hypertension and that its usefulness in patients without these conditions isn’t well established.2
The US Preventive Services Task Force recommends against screening EKGs in adults at low risk for CHD events (grade D recommendation).10
PROBABLY NOT. Although certain electrocardiogram (EKG) findings in asymptomatic adults are associated with increased mortality (strength of recommendation [SOR]: A, high-quality cohort studies), no randomized trials demonstrate that any intervention based on abnormal screening EKGs improves outcomes in this group of patients. Comparison to a baseline EKG has a minimal effect on emergency department (ED) management.(SOR: B, 2 prospective studies and one retrospective study).
Evidence summary
The US Pooling Project divided EKG abnormalities into major and minor findings.1 A number of large cohort studies have shown that both major and minor findings are associated with an elevated odds ratio for mortality (TABLE).1-5 However, these studies, completed before the development of modern medical management of acute coronary syndrome and stable coronary artery disease, may no longer estimate mortality accurately. Moreover, no studies have examined the effect of screening EKGs on coronary heart disease (CHD) outcomes.
Neither major nor minor EKG abnormalities linked to higher mortality
A 2012 cohort study—which included Q-waves as major criteria and examined fewer minor abnormalities than previous studies—followed 2192 patients 70 to 79 years of age for 8 years.6 The study enrolled a higher percentage of women and blacks than earlier investigations had.
Major EKG abnormalities predicted an increase in CHD events (hazard ratio [HR]=1.51; 95% confidence interval [CI], 1.20-1.90) as did minor abnormalities (HR=1.35; 95% CI, 1.02-1.81). In contrast to earlier studies, which tended to enroll younger patients, neither type of abnormality was associated with a significantly increased risk of all-cause mortality.6
Including EKG abnormalities in a regression model of traditional risk factors improved stratification (overall net reclassification improvement [NRI]=7.4%; 95% CI, 3.1%-19.0%).6 No low-risk patients were reclassified as high risk and no high-risk patients were reclassified as low risk. Overall, 156 intermediate risk patients were correctly reclassified and an equal number were incorrectly reclassified. Adding EKG abnormalities to the Framingham Risk Score (which hasn’t been validated in adults >75 years) didn’t significantly improve stratification (NRI=5.7%; 95% CI, −0.4% to 11.8%).6
Comparing ED with baseline EKGs has little effect on management
A 1980 retrospective study looked at 236 patients with acute chest pain and no known CHD who were seen in the ED. Comparing routine baseline EKGs obtained before ED presentation for 6 of 41 patients with equivocal EKGs in the ED—including T-wave inversions, nonspecific T-wave and ST-segment abnormalities, and bundle branch blocks—prevented 2 admissions (no EKG change from baseline) and caused 4 unnecessary admissions (EKG changed from baseline with no subsequent evidence of acute coronary syndromes).7
A 1985 prospective study of 84 ED patients, in which treating physicians were given baseline EKGs after committing to an initial disposition plan, showed that the baseline EKG altered the decision to admit or discharge in only one case.8
A 1990 prospective multicenter study of 5673 patients older than 30 years—41% of whom had known CHD—reported that when the current EKG was consistent with ischemia or infarction, a baseline EKG showing the changes to be old (10% of study population) increased the likelihood that the patient would be discharged from the ED to home (26% vs 12%; risk difference=14%; 95% CI, 7%-23%). Unlike previous studies, however, the exact role of the baseline EKG in the admission decision was isolated not by study design but rather by multivariate logistic regression modeling.9
Recommendations
The 2010 American College of Cardiology Foundation/American Heart Association (ACCF/AHA) guideline for assessment of cardiovascular risk in asymptomatic adults states that a resting EKG is probably indicated in patients with diabetes and hypertension and that its usefulness in patients without these conditions isn’t well established.2
The US Preventive Services Task Force recommends against screening EKGs in adults at low risk for CHD events (grade D recommendation).10
1. Sosenko J, Gardner L. Relationship of blood pressure, serum cholesterol, smoking habit, relative weight and ECG abnormalities to incidence of major coronary events: final report of the pooling project. J Chronic Dis. 1978;31:201-306.
2. Greenland P, Alpert J, Beller G, et al. 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2010;56:e50-e103.
3. Sox HC Jr, Garber AM, Littenberg B. The resting electrocardiogram as a screening test. A clinical analysis. Ann Intern Med. 1989;111:489-502.
4. DeBaquer D, De Backer G, Kornitzer M, et al. Prognostic value of ECG findings for total, cardiovascular disease, and coronary heart disease death in men and women. Heart. 1998;80: 570-577.
5. Whinnicup P, Goya W, Marcarlane P, et al. Resting electrocardiogram and risk of coronary heart disease in middle-aged British men. J Cardiovasc Risk. 1995;2:533-543.
6. Auer R, Bauer DC, Marques-Vidal P, et al. Association of major and minor ECG abnormalities with coronary heart disease events. JAMA. 2012;307:1497-1505.
7. Rubenstein LZ, Greenfield S. The baseline ECG in the evaluation of acute cardiac complaints. JAMA. 1980;244:2536-2539.
8. Hoffman JR, Igarashi E. Influence of electrocardiographic findings on admission decisions in patients with acute chest pain. Am J Med. 1985;79:699-707.
9. Lee TH, Cook EF, Weisberg MC, et al. Impact of the availability of a prior electrocardiogram on the triage of the patient with acute chest pain. J Gen Intern Med. 1990;5:381-388.
10. Chou R, Arora B, Dana T, et al. Screening asymptomatic adults with resting or exercise electrocardiography: a review of the evidence for the US Preventive Services Task Force. Ann Intern Med. 2011;155:375-385.
1. Sosenko J, Gardner L. Relationship of blood pressure, serum cholesterol, smoking habit, relative weight and ECG abnormalities to incidence of major coronary events: final report of the pooling project. J Chronic Dis. 1978;31:201-306.
2. Greenland P, Alpert J, Beller G, et al. 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2010;56:e50-e103.
3. Sox HC Jr, Garber AM, Littenberg B. The resting electrocardiogram as a screening test. A clinical analysis. Ann Intern Med. 1989;111:489-502.
4. DeBaquer D, De Backer G, Kornitzer M, et al. Prognostic value of ECG findings for total, cardiovascular disease, and coronary heart disease death in men and women. Heart. 1998;80: 570-577.
5. Whinnicup P, Goya W, Marcarlane P, et al. Resting electrocardiogram and risk of coronary heart disease in middle-aged British men. J Cardiovasc Risk. 1995;2:533-543.
6. Auer R, Bauer DC, Marques-Vidal P, et al. Association of major and minor ECG abnormalities with coronary heart disease events. JAMA. 2012;307:1497-1505.
7. Rubenstein LZ, Greenfield S. The baseline ECG in the evaluation of acute cardiac complaints. JAMA. 1980;244:2536-2539.
8. Hoffman JR, Igarashi E. Influence of electrocardiographic findings on admission decisions in patients with acute chest pain. Am J Med. 1985;79:699-707.
9. Lee TH, Cook EF, Weisberg MC, et al. Impact of the availability of a prior electrocardiogram on the triage of the patient with acute chest pain. J Gen Intern Med. 1990;5:381-388.
10. Chou R, Arora B, Dana T, et al. Screening asymptomatic adults with resting or exercise electrocardiography: a review of the evidence for the US Preventive Services Task Force. Ann Intern Med. 2011;155:375-385.
Evidence-based answers from the Family Physicians Inquiries Network