User login
Key clinical point: Cognitive reserve (CR) is strongly associated with cognitive function in patients with multiple sclerosis (MS); CR along with disability and depressive symptoms explained up to roughly 23.7% of the cognitive performance.
Major finding: Cognitive impairment (CI) was detected in 202 (38.4%) patients. The CR Index questionnaire (CRIq) score was lower in patients with CI vs. those without (94.8±11.6 vs. 102.2±14.1; P less than .001). CRIq score significantly correlated with information-processing speed, verbal memory, and visuospatial memory (P less than .001 for all). Higher CRIq was associated with lower disability and depressive symptoms (P less than .001 for both).
Study details: Cross-sectional study of 526 MS outpatients (70.9% female patients; mean age, 41.7±11.1 years); CR was assessed by the CRIq.
Disclosures: No study sponsor was identified. Dr. Bakirtzis and Prof. Grigoriadis reported receiving research funding and/or honoraria from multiple pharmaceutical companies. The remaining authors reported no conflict of interest.
Citation: Artemiadis A et al. Mult Scler Relat Disord. 2020 Mar 7. doi: 10.1016/j.msard.2020.102047.
Key clinical point: Cognitive reserve (CR) is strongly associated with cognitive function in patients with multiple sclerosis (MS); CR along with disability and depressive symptoms explained up to roughly 23.7% of the cognitive performance.
Major finding: Cognitive impairment (CI) was detected in 202 (38.4%) patients. The CR Index questionnaire (CRIq) score was lower in patients with CI vs. those without (94.8±11.6 vs. 102.2±14.1; P less than .001). CRIq score significantly correlated with information-processing speed, verbal memory, and visuospatial memory (P less than .001 for all). Higher CRIq was associated with lower disability and depressive symptoms (P less than .001 for both).
Study details: Cross-sectional study of 526 MS outpatients (70.9% female patients; mean age, 41.7±11.1 years); CR was assessed by the CRIq.
Disclosures: No study sponsor was identified. Dr. Bakirtzis and Prof. Grigoriadis reported receiving research funding and/or honoraria from multiple pharmaceutical companies. The remaining authors reported no conflict of interest.
Citation: Artemiadis A et al. Mult Scler Relat Disord. 2020 Mar 7. doi: 10.1016/j.msard.2020.102047.
Key clinical point: Cognitive reserve (CR) is strongly associated with cognitive function in patients with multiple sclerosis (MS); CR along with disability and depressive symptoms explained up to roughly 23.7% of the cognitive performance.
Major finding: Cognitive impairment (CI) was detected in 202 (38.4%) patients. The CR Index questionnaire (CRIq) score was lower in patients with CI vs. those without (94.8±11.6 vs. 102.2±14.1; P less than .001). CRIq score significantly correlated with information-processing speed, verbal memory, and visuospatial memory (P less than .001 for all). Higher CRIq was associated with lower disability and depressive symptoms (P less than .001 for both).
Study details: Cross-sectional study of 526 MS outpatients (70.9% female patients; mean age, 41.7±11.1 years); CR was assessed by the CRIq.
Disclosures: No study sponsor was identified. Dr. Bakirtzis and Prof. Grigoriadis reported receiving research funding and/or honoraria from multiple pharmaceutical companies. The remaining authors reported no conflict of interest.
Citation: Artemiadis A et al. Mult Scler Relat Disord. 2020 Mar 7. doi: 10.1016/j.msard.2020.102047.